ShieldPer fess Azure and Gules, on a pile Or, conjoined within a horseshoe of the third, nail holes pierced of the field, two mullets palewise of the first.
CrestThat for the regiments and separate battalions of the Massachusetts Army National Guard: On a wreath of the colors Or and Azure, a dexter arm embowed, clothed Blue and ruffed White Proper and hand grasping a broad sword Argent the pommel and hilt Or.
ShieldYellow is the color associated with Cavalry. The horseshoe symbolizes the mission and functions of the organization. The divided shield alludes to the Pacific and European areas in which elements of the former Regiment served during World War I and World War II. The pile, simulating an arrowhead, refers to the assault landing in the Philippines while the two stars refer to the Presidential Unit Citation (Navy) and Philippine Presidential Unit Citation awarded to an element of former Regiment.
CrestThe crest is that of the Massachusetts Army National Guard.
The coat of arms was originally approved for the 26th Cavalry Regiment on 7 January 1965. It was amended to revise the symbolism of the shield on 21 November 1969. The insignia was redesignated for the 110th Cavalry with the symbolism revised effective 1 February 1988.