A gold color metal and enamel device 1 1/8 inches (2.86 cm) in height overall consisting of a simulated Greek cross composed of a white horizontal stretcher in front of a white wavy vertical stripe extending over and in front of a maroon disc, and two gold diagonal flashes adjoining the base of the stripe and disc respectively extending to the left and right in back of the lower handles of the stretcher and terminating on each side below an undulating arched maroon scroll enclosing the sides and curved over the top of the device inscribed "PRIORITY:" on the left and top, and "LIFE" on the right in gold letters.
Maroon and white are the colors used for the Army Medical Department. The central disc and wavy stripe denote the Hospital's World War II campaign service in Central Europe and the Rhineland. The disc, additionally, together with the stretcher and flashes, refer to the swift action in providing hospitalization within the combat zone, and preparation of patients for evacuation to other medical facilities when required. The simulated cross suggests the emblem for aid and assistance.
The distinctive unit insignia was originally approved for the 385th Evacuation Hospital on 24 May 1971. It was redesignated for the 385th Combat Support Hospital on 12 August 1975.