An oval gold color metal and enamel device 1 1/8 inches (2.86 cm) in height overall, divided horizontally blue and gold, consisting of a red Greek cross bearing a gold leopard's face, the upper arm of the cross between three gold fleurs-de-lis, a maroon scroll circumscribed on the gold portion of the oval inscribed "PRIDE EXCELLENCE SERVICE" in gold letters.
The red cross, symbolic of aid and assistance, refers to the overall mission of the Hospital. The fleurs-de-lis represent the unit's service in France during World War I, and the leopard's face, suggested by the arms of Shropshire, England, symbolizes the unit's service there during World War II.
The distinctive unit insignia was originally approved for the 350th Evacuation Hospital on 19 March 1970. It was redesignated for the 350th Combat Support Hospital with the description revised, effective 17 September 1993.