A gold color metal and enamel device 1 1/8 inches (2.86 cm) in height overall consisting of a red cross bearing a gold heraldic rose all above and resting on top of a gold inverted equilateral triangle bearing a blue fleur-de-lis, all with a maroon scroll, the upper portion parallel along the sides of the vertical stem of the cross, enarched across the top and the lower portion enarched to base from the outer horizontal arms and passing behind the triangle, the upper arch inscribed "SAVE," the lower left inscribed "SERVE," and the lower right inscribed "SUPPORT" all in gold letters.
Maroon is the color used for the Army Medical Department and the red represents the Hospital. The fleur-de-lis refers to France where the unit served during World War I, with the heraldic rose symbolizing England and the organization's service there during World War II. The "Golden Triangle," symbol of the city of Pittsburgh, Pennsylvania, denotes the original homesite of the 339th General Hospital.
The distinctive unit insignia was originally approved for the 339th General Hospital on 18 July 1969. It was redesignated for the 339th Combat Support Hospital on 15 July 1997.