A device of gold color metal and enamel 1 1/8 inches (2.86 cm) in height overall consisting of a continuous maroon scroll formed like an equilateral triangle with one point up, the angles rounded and the sides curved inwards to touch a white life ring supported by a green cross with splayed and rounded ends; on the scroll in gold letters the word "VERSATILE" to the left, "SKILLED" to the right and the word "STRONG" across the bottom.
Maroon and white are the colors of the Medical Department. The continuous maroon scroll indicates the type of service provided by the Hospital and its pear-shape is symbolic of the human heart. The cross is a reference to the expedition of Christopher Columbus, the namesake of the city of Columbus, Ohio, location site of the 2291st Hospital. The color green is for health and life and the life ring, alluding to the saving of lives, also suggests the initial "O" for the state of Ohio.
The distinctive unit insignia was approved on 25 February 1969.