A gold color metal and enamel device 1 3/16 inches (3.02 cm) in height overall consisting of a red Greek cross bearing throughout a blue cross all crested by a gold lance cronel and surmounted at center by a seven-pointed white star, all enclosed by a maroon scroll arched above the arms of the cross and terminating at the lance cronel, baring the Latin inscription "MISSIO MISERICORDIAE" all in gold letters.
Maroon and white are the colors used for the Army Medical Department, and a red cross is symbolic of aid. The seven-pointed white star is taken from the flag of Australia and refers to the Australian administered island of New Guinea and the unit's campaign participation there, and the blue cross denotes the Presidential Unit Citation awarded the organization for the Papua Campaign, both during World War II. The lance cronel used to protect the point of the lance during the middle ages, simulates a crown, one of the symbols of St. Louis, know for devoted care to fellow humans, and it also refers to the unit's present home site.
The distinctive unit insignia was originally approved for the 25th Surgical Hospital on 13 January 1971. It was redesignated for the 25th Combat Support Hospital on 11 February 1977. The insignia was redesignated for the 25th Surgical Hospital on 29 February 1984.